個人簡介：
廖茂富，生命科學(xué)學(xué)院講席教授，博士生導(dǎo)師。1999年畢業(yè)于清華大學(xué)生物科學(xué)與技術(shù)系，2006年獲美國愛因斯坦醫(yī)學(xué)院博士學(xué)位，之后在加州大學(xué)舊金山分校進(jìn)行博士后工作。2014年至2022年，先后任哈佛大學(xué)醫(yī)學(xué)院助理教授、副教授。主要使用冷凍電鏡和生物化學(xué)方法研究生物大分子的結(jié)構(gòu)與機(jī)制。于2022年7月全職回國加入南方科技大學(xué)生命科學(xué)學(xué)院。
研究領(lǐng)域：
廖茂富課題組的研究領(lǐng)域包括：
1. 發(fā)展生物電鏡方法學(xué)以開拓新科研領(lǐng)域；
2. 揭示生物大分子運作的精細(xì)機(jī)制；
3. 使用生物的結(jié)構(gòu)和機(jī)制信息來革新醫(yī)療手段。
代表文章：
1: Liu D*, Thélot FA*, Piccirilli JA, Liao M#, Yin P#. Sub-3-? cryo-EM structure of RNA enabled by engineered homomeric self-assembly. Nat Methods. 2022 May;19(5):576-585. doi: 10.1038/s41592-022-01455-w. Epub 2022 May 2. PMID: 35501384.
2: Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M. Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science. 2021 Oct 29;374(6567):580-585. doi: 10.1126/science.abi9009. Epub 2021 Sep 23. PMID: 34554829; PMCID: PMC9109178.
3: Sharma S*, Zhou R*, Wan L, Feng S, Song K, Xu C, Li Y#, Liao M#. Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins. Nat Commun. 2021 Aug 3;12(1):4687. doi: 10.1038/s41467-021-24965-1. PMID: 34344901; PMCID: PMC8333309.
4: Orlando BJ, Liao M. ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun. 2020 May 8;11(1):2264. doi: 10.1038/s41467-020-16155-2. PMID: 32385283; PMCID: PMC7210939.
5: Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M#, Walther TC#, Farese RV Jr.# Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 May;581(7808):323-328. doi: 10.1038/s41586-020-2289-6. Epub 2020 May 13. PMID: 32433611; PMCID: PMC7398557.
6: Li Y*, Orlando BJ*, Liao M. Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature. 2019 Mar;567(7749):486-490. doi: 10.1038/s41586-019-1025-6. Epub 2019 Mar 20. PMID: 30894744; PMCID: PMC6532066.
7: Srivastava AP*, Luo M*, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M#, Mueller DM#. High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane. Science. 2018 May 11;360(6389):eaas9699. doi: 10.1126/science.aas9699. Epub 2018 Apr 12. PMID: 29650704; PMCID: PMC5948177.
8: Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M. Structural basis of MsbA-mediated lipopolysaccharide transport. Nature. 2017 Sep 14;549(7671):233-237. doi: 10.1038/nature23649. Epub 2017 Sep 6. PMID: 28869968; PMCID: PMC5759761.
9: Schoebel S*, Mi W*, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA#, Liao M#. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature. 2017 Aug 17;548(7667):352-355. doi: 10.1038/nature23314. Epub 2017 Jul 6. PMID: 28682307; PMCID: PMC5736104.
10: Liao M*, Cao E*, Julius D#, Cheng Y#. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013 Dec 5;504(7478):107-12. doi: 10.1038/nature12822. PMID: 24305160; PMCID: PMC4078027.
課題組網(wǎng)站：https://liao.bio.sustech.edu.cn/
